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US 12,545,896 B2Granted
Growth inhibitor
AssigneeOrizuru Therapeutics, Inc.
InventorsKensuke Sakuma, Noriko Yamazoe, Taro Toyoda, Shuhei Konagaya
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Abstract
An object of the present invention is to provide an approach of removing non-endocrine unintended cells coexisting with insulin-secreting cells obtained by the differentiation. The present invention relates to a method for producing an insulin-producing cell population, comprising the step of treating an insulin-producing cell population obtained by the differentiation from pluripotent stem cells with a PLK inhibitor.
Claims9
A method for producing an insulin-producing cell population comprising CHGA-negative cells at a proportion of 30% or less comprising the steps of:
- (a) providing an insulin-producing cell population, wherein the insulin producing cell population is produced from pluripotent stem cells,
- (b) contacting the population of (a) with a PLK inhibitor;
- and
- (c) obtaining an insulin-producing cell population comprising CHGA-negative cells at a proportion of 30% or less.
1 more element
Dependencies are inferred from the claim text.