Method for treating a degenerative neurological disorders comprising administering ASM inhibitor
AssigneeKyungpook National University Industry-Academic Cooperation Foundation
InventorsJae Sung Bae, Hee Kyung Jin, Min Hee Park
Life of this patent
Estimating the term…
Abstract
The present invention relates to a method for treating degenerative neurological disorders in a subject in need thereof, comprising administering to a subject in need thereof a therapeutically effective amount of a composition comprising an acid sphingomyelinase (ASM) activity inhibitor as an active ingredient.
Claims3
A method for treating Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), depression, or cerebral infarction in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a composition comprising an acid sphingomyelinase (ASM) activity inhibitor selected from (i) an antisense nucleotide or miRNA selected from SEQ ID NOs:
- 1-6, or (ii) a monoclonal antibody which comprises a heavy chain variable region (VH) comprising heavy chain complementarity determining region 1 (CDR1) containing SEQ ID NO:
- 17, heavy chain complementarity determining region 2 (CDR2) containing SEQ ID NO:
- 18, and heavy chain complementarity determining region 3 (CDR3) containing SEQ ID NO:
- 19, and a light chain variable region (VL) comprising light chain complementarity determining region 1 (CDR1) containing SEQ ID NO:
- 20, light chain complementarity determining region 2 (CDR2) containing SEQ ID NO:
- 21, and light chain complementarity determining region 3 (CDR3) containing SEQ ID NO:
- 22 as an active ingredient.
Dependencies are inferred from the claim text.