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US 12,545,721 B2Granted
Anti-tropinin T antibodies
AssigneeRoche Diagnostics Operations, Inc.
InventorsSarah Liedke, Frank Kroner, Michael Schraeml
Life of this patent
Estimating the term…
Abstract
The present invention relates to an improved variant monoclonal antibody binding to cardiac troponin T and having a better KD than the parent monoclonal antibody 11-7.
Claims11
An antibody that specifically binds to human cardiac troponin T (SEQ ID NO:1), the antibody comprising complementarity-determining regions (CDRs), wherein the CDRs comprise the following amino acid sequences:
- (i) in the light chain variable domain a CDR1 comprising the amino acid sequence of SEQ ID NO:2, a CDR2 comprising the amino acid sequence of SEQ ID NO:3, and a CDR3 comprising the amino acid sequence of SEQ ID NO:4, and
- (ii) in the heavy chain variable domain a CDR1 comprising the amino acid sequence of SEQ ID NO:5, a CDR2 comprising the amino acid sequence of SEQ ID NO:6 and a CDR3 comprising the amino acid sequence of SEQ ID NO:7.
An antibody comprising:
- (i) a light chain variable domain comprising the amino acid sequence of SEQ ID NO:27, and
- (ii) a heavy chain variable domain comprising the heavy chain variable domain of SEQ ID NO:28.
An antibody comprising:
- (i) a light chain variable domain consisting of the amino acid sequence of SEQ ID NO:27, and
- (ii) a heavy chain variable domain consisting of the amino acid sequence of SEQ ID NO:28.
Dependencies are inferred from the claim text.