Multiple antigen presenting immunogenic composition, and methods and uses thereof
AssigneeChildren's Medical Center Corporation
InventorsRichard Malley, Yingjie Lu, Fan Zhang
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Abstract
The present embodiments provide for an immunogenic multiple antigen presenting system comprising a polymer to which antigens are associated by complementary affinity molecules. For example, the polymer can be a polysaccharide, or antigenic polysaccharide, to which protein or peptide antigens from the same or different pathogens are indirectly linked. The present immunogenic compositions can elicit both humoral and cellular immune responses to one or multiple antigens at the same time.
Claims24
An immunogenic composition comprising one or more species of immunogenic complexes, wherein each of the one or more species of immunogenic complexes comprises:
- (a) an immunologically effective amount of a biotinylated polysaccharide antigen;
- and
- (b) a biotin-binding protein associated with an immunologically effective amount of one or more distinct peptide or polypeptide antigens;
- wherein in each species of the immunogenic complexes, the biotinylated polysaccharide antigen is non-covalently associated with the biotin-binding protein to link the polysaccharide antigen and the one or more peptide or polypeptide antigens;
- and
- wherein at least one of the peptide or polypeptide antigens is a Streptococcus pneumoniae antigen.
Dependencies are inferred from the claim text.