IBAT inhibitors for the treatment of liver diseases
AssigneeAlbireo AB
InventorsPer-Göran Gillberg, Hans Graffner, Ingemar Starke
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Abstract
The present invention regards specific IBAT inhibitors useful in the prophylaxis and/or treatment of a liver disease. It also relates to compositions comprising these IBAT inhibitors, a method for treatment of the disorders and a kit comprising the substances or the compositions.
Claims2
A method for treating pruritus of cholestatic liver disease in a subject, the method comprising orally administering to a subject in need of such treatment a therapeutically effective amount an IBAT inhibitor, wherein the IBAT inhibitor is a hydrated form of 1,1-dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(N—{(R)-α-[N—((S)-1-carboxypropyl) carbamoyl]-4-hydroxybenzyl} carbamoylmethoxy)-2,3,4,5-tetrahydro-1,2,5-benzothiadiazepine, wherein the cholestatic liver disease is Alagille syndrome (ALGS).
A method for treating pruritus of cholestatic liver disease in a subject, the method comprising orally administering to a subject in need of such treatment a therapeutically effective amount an IBAT inhibitor, wherein the IBAT inhibitor is a hydrated form of 1,1-dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(N—{(R)-α-[N—((S)-1-carboxypropyl) carbamoyl]-4-hydroxybenzyl} carbamoylmethoxy)-2,3,4,5-tetrahydro-1,2,5-benzothiadiazepine, wherein the cholestatic liver disease is progressive familial intrahepatic cholestasis (PFIC).
Dependencies are inferred from the claim text.