C4-modified oleanolic acid derivatives for inhibition of IL-17 and other uses

A compound of the formula:

• wherein:
• R3 is hydrogen, hydroxy, or R3 is taken together with Y as described below;
• Y is heteroaryl(C≤8) or substituted heteroaryl(C≤8);
• —C(O)Rc, wherein
• Rc is:
• hydroxy, alkoxy(C≤8), substituted alkoxy(C≤8), alkylamino(C≤8), substituted alkylamino(c≤8), dialkylamino(C≤8), or substituted dialkylamino(C≤8);
• —NRdC(O)Re, wherein
• Rd is hydrogen;
• and
• Re is alkyl(C≤8), alkoxy(C≤8), or a substituted version of either group;
• or
• Y is taken together with R3 and is-C(O)O—;
• and
• R5 is acyloxy(C≤8) or substituted acyloxy(C≤8);
• wherein when the terms alkyl, alkoxy, acyloxy, alkylamino, dialkylamino, and heteroaryl are used with the substituted modifier, one or more hydrogen atom has been independently replaced by —OH, —F, —Cl, —Br, —I, —NH2, —NO2, —CO2H, —CO2CH3, —CN, —SH, —OCH3, —OCH2CH3, —C(O)CH3, —NHCH3, —NHCH2CH3, —N(CH3)2, —C(O)NH2, —C(O)NHCH3, —C(O)N(CH3)2, —OC(O)CH3, —NHC(O)CH3, —S(O)2OH, or —S(O)2NH2;
• or a pharmaceutically acceptable salt thereof.