Compounds for inhibiting neovascularization factors and use thereof
AssigneesUnist (Ulsan National Institute of Science and Technology), Smartin Bio Inc.
InventorsByoung Heon Kang, So-Yeon Kim, Nam Gu Yoon, Changwook Lee, Dong Ho Park
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Abstract
The present specification relates to compounds for inhibiting neovascularization factors and use thereof. Furthermore, the present specification relates to methods for treating neovascularization diseases using the compounds.
Claims8
A compound of structure represented by the following [Chemical Formula 1], a pharmaceutically acceptable salt or a prodrug thereof:
- wherein,
- R1 is H, C1-5 alkyl, C2-5 alkenyl, or C2-5 alkynyl;
- R3 and R4 are independently C1-5 alkoxy;
- R2 and R5 are independently hydroxy, alkoxy or halogen and at least one of R2 and R5 is halogen;
- L is —(CH2)n—;
- and
- n is an integer from 5 to 12.
A method of treating a neovascular ocular disease in a subject in need thereof, comprising administering to said subject a therapeutically effective amount of a compound of a structure represented by the following [Chemical Formula 1], a pharmaceutically acceptable salt or a prodrug thereof:
- wherein,
- R1 is H, C1-5 alkyl, C2-5 alkenyl, or C2-5 alkynyl;
- R3 and R4 are independently C1-5 alkoxy;
- R2 and R5 are independently hydroxy, alkoxy or halogen and at least one of R2 and R5 is halogen;
- L is —(CH2)n—;
- and
- n is an integer from 5 to 12.
Dependencies are inferred from the claim text.