Macrocyclic LRRK2 kinase inhibitors

A compound of formula (I):

• wherein:
• R represents a hydrogen atom, a halogen atom or an alkyl group,
• Z1, Z2, Z3, each independently represent a carbon or a nitrogen atom, wherein the 6-membered cycle containing Z1, Z2 and Z3 can have 0, 1 or 2 nitrogen atoms;
• —X1- is absent or represents —O—, —S—, or —N(R′a)-, wherein R′a represents a hydrogen atom or an alkyl group;
• —X2- represents an alkanediyl group optionally substituted by one or more substituents, which may be identical or different, selected from a halogen atom, polyhalogenoalkyl group, alkoxy group, hydroxy group, amino group, alkylamino group, dialkylamino group and cyano group,
• wherein the carbon atom in the alpha position of —N(Ra), and the carbon atom in alpha position of —X1- when —X1- represents —O—, —S—, or —N(R′a)-, cannot be substituted with an oxygen or a nitrogen heteroatom;
• —X3- represents an alkanediyl group optionally substituted by one or more substituents, which may be identical or different, selected from a halogen atom, polyhalogenoalkyl group, alkoxy group, hydroxy group, amino group, alkylamino group, dialkylamino group, cyano group, cycloalkyl group and heterocycloalkyl group, wherein the carbon atom in alpha position of —O—, and the carbon atom in alpha position of A1 when A1 represents a nitrogen atom, cannot be substituted with an oxygen or a nitrogen heteroatom;
• Ra represents a hydrogen atom or an alkyl group,
• wherein, when Ra represents an alkyl group, one carbon atom of Ra can be linked to a carbon atom of —X2-, or to a carbon atom of —X3- to form a cyclic moiety having 5 or 6 ring-members;
• A represents
• an aromatic or partially hydrogenated cyclic group of the formula (a):
• wherein
• A1 and A4 each independently represent a carbon atom or a nitrogen atom,
• A2, A3 and A5 each independently represents a carbon atom, an oxygen atom, a sulfur atom or a nitrogen atom,
• wherein A1, A2, A3, A4 and A5 cannot simultaneously represent a heteroatom,
• or an aromatic or partially hydrogenated cyclic group of the formula (b):
• wherein A′1, A′2, A′3 and A′4 each independently represent a carbon atom or a nitrogen atom,
• wherein * means that the bond is linked to X3, and wherein
• the aromatic or partially hydrogenated cyclic group A may be optionally substituted with one or more substituents, which may be identical or different, selected from a halogen atom, alkyl group, alkoxy group, hydroxy group, oxo group, alkoxyalkyl group, alkoxyalkoxy group, polyhalogenoalkyl group, polyhalogenoalkoxy group, heterocycloalkyl group, heterocycloalkylalkyl group, (alkoxyalkyl)(alkyl)amino group, amino group, alkylamino group, dialkylamino group, cycloalkyl group, (heterocycloalkyl)(alkyl)amino group, dialkylaminoalkyl group, heterocycloalkylalkoxy group, cyano group and cyanoalkyl group,
• wherein the heterocycloalkyl and cycloalkyl group may be optionally substituted by one or more substituents selected from alkyl group, halogen atoms, polyhalogenoalkyl group, polyhalogenoalkoxy group, alkoxy group, alkoxyalkyl group, hydroxy group, cyano group and oxo group;
• its enantiomers, diastereoisomers, tautomers, racemic, hydrates, solvates, N-oxide, isotopes, deuterated derivatives and addition salts thereof with a pharmaceutically acceptable acid or base.