Dispiropyrrolidine derivatives

A compound represented by general formula (1) or a salt thereof:

• wherein ring A represents a spiro-linked 4- or 6-membered saturated hydrocarbon ring optionally substituted with one or more substituents selected from Group 1, or a spiro-linked 6-membered saturated heterocyclic ring optionally substituted with one or more substituents selected from Group 1;
• ring B represents a benzene ring optionally substituted with one or more substituents selected from Group 2, a pyridine ring optionally substituted with one or more substituents selected from Group 2, or a pyrimidine ring optionally substituted with one or more substituents selected from Group 2;
• R1 represents an aryl group optionally substituted with one or more substituents selected from Group 3, a heteroaryl group optionally substituted with one or more substituents selected from Group 3, a C3-C6 cycloalkyl group optionally substituted with one or more substituents selected from Group 3, or a C3-C6 cycloalkenyl group optionally substituted with one or more substituents selected from Group 3;
• R2 represents a C1-C6 alkyl group optionally substituted with one to three halogen atoms or one to three hydroxy groups, or a hydrogen atom;
• and
• R3 represents a group represented by the following general formula (3) or (4):
• wherein in formula (3), the broken line in the ring structure indicates that the bond may be a double bond,
• R6 represents a C1-C6 alkyl group optionally substituted with one or more substituents selected from Group 4, a carbamoyl group optionally substituted with one or more substituents selected from Group 5, a 5- or 6-membered nitrogen-containing heteroaryl group optionally substituted with an oxo group or one or more C1-C6 alkyl groups optionally substituted with an oxo group or one hydroxy group, a hydroxy group, or —NR′R″,
• wherein R′ and R″ each independently represent a C1-C6 alkyl group optionally substituted with one to three halogen atoms, an oxo group, or one to three hydroxy groups, a C3-C4 cycloalkyl group optionally substituted with one to three halogen atoms or one to three hydroxy groups, or a hydrogen atom, or R′ and R″ together with the nitrogen atom to which R′ and R″ are bonded may together form a 4- to 7-membered nitrogen-containing heterocyclic group optionally substituted with one or more substituents selected from a C1-C6 alkyl group and a hydroxy group,
• R7 represents a C1-C6 alkyl group optionally substituted with one hydroxy group, a hydroxy group, or a hydrogen atom, or
• R6 and R7 may together form a spiro-linked 4- to 6-membered hydrocarbon ring or a spiro-linked 4- to 6-membered nitrogen-containing heterocyclic ring,
• R8 is absent or represents one or more substituents selected from a hydroxy group, a C1-C6 alkyl group, and a C1-C6 alkoxy group, and
• Z represents O;
• and in formula (4),
• R9 represents a C1-C6 alkyl group optionally substituted with one or more substituents selected from Group 4, a carbamoyl group optionally substituted with one or more substituents selected from Group 5, a 5- or 6-membered nitrogen-containing heteroaryl group optionally substituted with an oxo group or one or more C1-C6 alkyl groups optionally substituted with an oxo group or one hydroxy group, a hydroxy group, or —NR′R″,
• wherein R′ and R″ each independently represent a C1-C6 alkyl group optionally substituted with one to three halogen atoms, an oxo group, or one to three hydroxy groups, a C3-C4 cycloalkyl group optionally substituted with one to three halogen atoms or one to three hydroxy groups, or a hydrogen atom, or R′ and R″ together with the nitrogen atom to which R′ and R″ are bonded may together form a 4- to 7-membered nitrogen-containing heterocyclic group optionally substituted with one or more substituents selected from a C1-C6 alkyl group and a hydroxy group,
• R10 represents a C1-C6 alkyl group optionally substituted with one hydroxy group, a hydroxy group, or a hydrogen atom, or
• R9 and R10 may together form a spiro-linked 4- to 6-membered hydrocarbon ring or a spiro-linked 4- to 6-membered nitrogen-containing heterocyclic ring, and
• R11 represents one or more substituents selected from a hydroxy group, a C1-C6 alkyl group, and a C1-C6 alkoxy group,
• wherein Group 1 represents a halogen atom, a C1-C6 alkyl group optionally substituted with one to three halogen atoms, a C1-C6 alkoxy group, or a cyano group,
• Group 2 represents a halogen atom, a C1-C6 alkyl group optionally substituted with one to three halogen atoms, a C3-C4 cycloalkyl group optionally substituted with one to three halogen atoms, a vinyl group, an ethinyl group, a cyano group, or a C1-C6 alkoxy group,
• Group 3 represents a halogen atom, a C1-C6 alkyl group optionally substituted with one to three halogen atoms or one to three hydroxy groups, a C3-C4 cycloalkyl group optionally substituted with one to three halogen atoms or one to three hydroxy groups, a vinyl group, an ethinyl group, a cyano group, —OR′, —NR′R″, —COOR′, or —CONHR′,
• wherein R′ and R″ each independently represent a C1-C6 alkyl group optionally substituted with one to three halogen atoms or one to three hydroxy groups, a C3-C4 cycloalkyl group optionally substituted with one to three halogen atoms or one to three hydroxy groups, or a hydrogen atom, or R′ and R″ together with the nitrogen atom to which R′ and R″ are bonded may together form a 4- to 7-membered nitrogen-containing heterocyclic group optionally substituted with one or more substituents selected from a C1-C6 alkyl group and a hydroxy group,
• Group 4 represents a halogen atom, a hydroxy group, a carbamoyl group, a morpholino group, a C1-C6 alkoxy group, a C1-C6 alkylsulfonyl group, or —NR′R″,
• wherein R′ and R″ each independently represent a C1-C6 alkyl group optionally substituted with one to three halogen atoms, one to three hydroxy groups, or an oxo group, a C3-C4 cycloalkyl group optionally substituted with one to three halogen atoms or one to three hydroxy groups, or a hydrogen atom, or R′ and R″ together with the nitrogen atom to which R′ and R″ are bonded may together form a 4- to 7-membered nitrogen-containing heterocyclic group optionally substituted with one or more substituents selected from a C1-C6 alkyl group and a hydroxy group, and
• Group 5 represents a C1-C6 alkyl group optionally substituted with one to three halogen atoms, one to three hydroxy groups, or a C1-C6 alkoxy group, a C3-C6 cycloalkyl group, a C1-C6 alkoxy group, or a tetrahydropyranyl group.