Loading patent…
AssigneeSt. Jude Children's Research Hospital
InventorsRichard E. Lee, Rajendra P. Tangallapally, Charles O. Rock, Suzanne Jackowski, Anne V. Edwards, Mi Kyung Yun, Chitra Subramanian, Robert Zamboni, T. Jagadeeswar Reddy
Estimating the term…
The present disclosure relates to chemical compounds that modulate pantothenate kinase (PanK) activity for the treatment of metabolic disorders (such as diabetes mellitus type II), neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
A method of modulating pantothenate kinase activity in a cell, the method comprising contacting at least one cell with an effective amount of a compound of the formula
A method of therapeutically treating a disorder associated with pantothenate kinase activity in a subject, the method comprising administering to the subject an effective amount of a compound of the formula
Dependencies are inferred from the claim text.