3,5-diaminobenzoic acid compound, and Pin1 inhibitor and therapeutic agent for inflammatory diseases using same
AssigneeAmenis Bioscience, Inc.
InventorsTomoichiro Asano, Yusuke Nakatsu, Hisanaka Ito, Takayoshi Okabe
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Abstract
The present invention provides: a compound represented by the following Formula (I) or a salt thereof, as well as a Pin1 inhibitor, a pharmaceutical composition, a therapeutic or prophylactic agent for inflammatory diseases, a therapeutic or prophylactic agent for fatty liver diseases, a therapeutic or prophylactic agent for obesity, and a therapeutic or prophylactic agent for COVID-19 that utilize the aforementioned compounds or the salts thereof to develop a group of novel compounds with an inhibitory activity against the function of Pin1 so as to use them as candidate compounds for medicaments.
Claims22
A compound represented by Formula (I), or a salt thereof:
- wherein ring A represents an optionally substituted monocyclic or polycyclic aromatic ring or heterocycle;
- R1 represents a group represented by any of the following Formulae (II) to (V):
- wherein ring B represents an optionally substituted monocyclic heterocycle, Rings C and D independently represent an optionally substituted monocyclic or polycyclic aromatic ring, heterocycle or cyclic hydrocarbon, and the rings B, C and D form a condensed ring
- wherein ring E represents an optionally substituted monocyclic heterocycle, ring F represents an optionally substituted monocyclic or polycyclic aromatic ring, heterocycle or cyclic hydrocarbon, and the rings E and F form a condensed ring
- wherein rings G and H independently represent an optionally substituted monocyclic or polycyclic aromatic ring or heterocycle
- wherein ring I represents an optionally substituted monocyclic aromatic ring or heterocycle, a ring J represents an optionally substituted monocyclic or polycyclic aromatic ring, heterocycle or cyclic hydrocarbon, the rings I and J form a condensed ring, and R6 represents a hydrogen atom, an optionally substituted hydrocarbon group, or an optionally substituted heterocyclic group;
- R2 represents a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group, or an optionally substituted amino group;
- R3 represents a hydrogen atom, an optionally substituted hydrocarbon group, or an optionally substituted heterocyclic group;
- R4 represents a hydrogen atom, an optionally substituted hydrocarbon group, or an optionally substituted heterocyclic group;
- R5 represents 0 to 3 identical or different substituents attached to the benzene ring;
- X represents a single bond, C1-2 alkylene group, —O— group, —CH2—O group, —CH2—NH—CO— group, or —CH2—NH—CO—O—CH2— group;
- and
- Y represents a single bond or C1-2 alkylene group.
Dependencies are inferred from the claim text.