Pharmaceutically acceptable salts of psilocin and uses thereof
AssigneeEleusis Therapeutics US, Inc.
InventorsDavid E. Nichols, Graham Johnson, Hooshang S. Zavareh, Claire Wombwell, Daniel Rixson, Peter Haddow, Carrie Sheard, Alexander Schwarz
Life of this patent
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Abstract
The present invention composition features pharmaceutically acceptable salts of psilocin and compositions thereof. The pharmaceutically acceptable salts of psilocin may be used to treat a disease or condition, such as a neurological injury, an inflammatory condition, chronic pain, or a psychological condition, in a subject in need thereof.
Claims13
A crystal form of a 2:1 succinate salt of psilocin having at least four, five, six, or seven peaks at diffraction angle 2θ(°) as provided in FIG. 4 (SUC Pattern 4) as measured by X-ray powder diffractometry.
A crystal form of a 1,5-naphthalenedisulfonic acid salt of psilocin having at least four, five, six, or seven peaks at diffraction angle 2θ (°) as provided in FIG. 7 or FIG. 14 (NAP Pattern 1) as measured by X-ray powder diffractometry.
A crystal form of a 1:1 tartrate salt of psilocin having at least four, five, six, or seven peaks at diffraction angle 2θ (°) as provided in FIG. 9 or FIG. 12 (TAR Pattern 3) as measured by X-ray powder diffractometry.
A crystal form of a 1:1 tartrate salt of psilocin having at least four, five, six, or seven peaks at diffraction angle 2θ (°) as provided in FIG. 10 (TAR Pattern 4) as measured by X-ray powder diffractometry.
A crystal form of a 1:1 tartrate salt of psilocin having at least four, five, six, or seven peaks at diffraction angle 2θ (°) selected from 6.7±0.5, 12.6±0.5, 13.4±0.5, 14.7±0.5, 15.8±0.5, 16.2±0.5, 17.2±0.5, 18.8±0.5, 19.9±0.5, 20.8±0.5, 21.8±0.5, 22.5±0.5, 23.4±0.5, 23.7±0.5, 24.7±0.5, 25.5±0.5, 26.5±0.5, 27.0±0.5, 28.5±0.5, and 29.4±0.5 (TAR Pattern 1) as measured by X-ray powder diffractometry.
A crystal form of a 2:1 succinate salt of psilocin having at least four, five, six, or seven peaks at diffraction angle 2θ (°) selected from 9.7±0.5, 11.2±0.5, 12.3±0.5, 13.8±0.5, 15.9±0.5, 16.4±0.5, 19.4±0.5, 20.0±0.5, 21.3±0.5, 22.6±0.5, 23.3±0.5, 23.5±0.5, 23.8±0.5, 24.5±0.5, 24.7±0.5, 25.0±0.5, 28.0±0.5, 28.3±0.5, 29.0±0.5, and 29.4±0.5 (SUC Pattern 3) as measured by X-ray powder diffractometry.
A pharmaceutical composition comprising (i) an aqueous solution having a pH of between about 3 and about 9 and (ii) between about 0.1 mg/ml and about 50 mg/ml of a pharmaceutically acceptable salt of psilocin, wherein said pharmaceutically acceptable salt is a 2:1 succinate salt, wherein the pharmaceutical composition is suitable for infusion.
A pharmaceutical composition comprising (i) an aqueous solution having a pH of between about 3 and about 9 and (ii) between about 0.1 mg/mL and about 50 mg/mL of a pharmaceutically acceptable salt of psilocin, wherein said pharmaceutically acceptable salt is a 1:1 tartrate salt, wherein the pharmaceutical composition is suitable for infusion.
A pharmaceutical composition comprising (i) an aqueous solution having a pH of between about 3 and about 9 and (ii) between about 0.1 mg/ml and about 50 mg/ml of a pharmaceutically acceptable salt of psilocin, wherein said pharmaceutically acceptable salt is a 2:1 salt of 1,5-naphthalenedisulfonic acid, a 1:1 salt of 1,5-naphthalenedisulfonic acid, or a mixture thereof, wherein the pharmaceutical composition is suitable for infusion.
Dependencies are inferred from the claim text.