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US 12,544,552 B1Granted
Therapy delivery system
AssigneeNirvaMed, Inc.
InventorsPramote Hochareon, Cynthia Clague, Cattleya Ounekeo, Panapat Uawithya, Troy Ziegler, Don Evans
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Abstract
A therapy delivery system for delivering therapy to a target region in a body includes an inflow channel and an outflow channel through which regulated inflow and inflow may be conveyed. The inflow and outflow is controlled by flow regulators in a manner to deliver a therapeutic agent to the target region and achieve a therapeutic response. A controller dynamically adjusts a ratio of inflow to outflow in response to an input that is related to changing physiological conditions.
Claims16
A method for controlling fluid flow in a human heart, the method comprising:
- (a) establishing a model cutoff frequency of a system including a coronary target region, wherein the target region is considered a low-pass filter;
- (b) controllably delivering an inflow pulse of fluidic inflow to the target region through a coronary vessel of the target region in an inflow volume within an inflow time period, wherein the fluid inflow has a therapeutic effect upon the target region;
- (b) controlling an outflow pulse of fluidic outflow from the target region in an outflow volume within an outflow time period, wherein a net volume is defined by a difference of the inflow volume and the outflow volume;
- and
- wherein the fluidic inflow pulse and the fluidic outflow pulse are relatively controlled to an adjustable ratio of inflow time period to outflow time period, and wherein a total time period from onset of the fluidic inflow pulse to termination of the fluidic outflow pulse, including any delay therebetween, is greater than an interval of the cutoff frequency of the target region.
2 more elements
Dependencies are inferred from the claim text.