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US 12,544,511 B2Granted
Systems and methods for pre-filled dual-chamber medical agent delivery
AssigneeKoska Family Limited
InventorsMarc Andrew Koska, Jeff Price, Hanjin In, Jae-Hyok Cha
Life of this patent
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Abstract
A pre-filled dual-chamber medical agent delivery system assembled and configured to allow delivery of a single dose of a combined therapeutic agent (e.g., vaccine, drug, medicament, etc.) from a Blow-Fill-Seal (BFS) vial to a patient. The delivery assembly generally includes a modular design consisting of separately constructed components cooperatively arranged and coupled to one another, such as to facilitate delivery of a reconstituted lyophilized agent to a patient.
Claims20
A pre-filled dual-chamber medical agent delivery system, comprising:
- a blow-fill-seal (BFS) bottle defining a radially collapsible fluid chamber having a fluid agent therein, a neck portion, an exterior flange formed on the neck portion, and a BFS seal at an end of the neck portion;
- a collar defining a first collar end and a second collar end, the first collar end comprising an interior seat into which the exterior flange is axially mated, the second collar end comprising collar threads, and a penetrating element disposed in an interior collar volume defined by the collar for penetrating the BFS seal of the BFS bottle, the collar further defining an outlet port extending from the second collar end for passage of the fluid agent;
- a modular chamber element defining a first chamber end and a second chamber end, the first chamber end comprising first chamber threads operative to be cooperatively mated with the collar threads of the collar, and the modular chamber element defining an interior chamber volume and comprising a chamber seal on an end surface defined at the second chamber end and comprising second chamber threads proximate to the second chamber end;
- a needle hub comprising hub threads that are operable to be cooperatively mated with the second chamber threads of the modular chamber element, the needle hub being coupled to a double-ended needle disposed through the needle hub and into the modular chamber element, the needle having a proximal or trailing piercing end and a distal or leading treatment end for application to a patient, the needle defining a needle passage;
- and
- a cap covering an administration end of the needle and the cap comprising an interior key that is operable to drive the needle hub to mate the hub threads and the second chamber threads to cause relative movement of the needle from a first transit position to a second activated position;
- wherein, in the second activated position, the piercing end of the needle penetrates the chamber seal of the modular chamber element with at least the piercing end of the needle being disposed within the interior chamber volume of the modular chamber element in spaced relation relative to the outlet port of the collar;
- wherein compression of the radially collapsible fluid chamber of the BFS bottle causes the fluid agent to be expelled through the outlet port of the collar and collected within the interior chamber volume of the modular chamber element and thereafter through the needle passage of the needle.
5 more elements
A pre-filled dual-chamber medical agent delivery system, comprising:
- a blow-fill-seal (BFS) bottle defining a radially collapsible fluid chamber having a treatment agent therein, a neck portion, an exterior flange formed on the neck portion, and a BFS seal at an end of the neck portion;
- a collar defining a first collar end and a second collar end, the first collar end comprising an interior seat into which the exterior flange is axially mated, the second collar end comprising collar threads, and a penetrating element disposed in an interior collar volume defined by the collar for penetrating the BFS seal of the BFS bottle, the collar further defining an outlet port extending from the second collar end for passage of the treatment agent from the BFS bottle;
- a modular chamber element defining a first chamber end and a second chamber end, the first chamber end comprising first chamber threads operative to be cooperatively mated with the collar threads of the collar, and the modular chamber element defining an interior chamber volume for collecting the treatment agent exiting the outlet port of the collar, the modular chamber element comprising a chamber seal on an end surface defined at the second chamber end and comprising second chamber threads proximate to the second chamber end;
- a hub comprising hub threads engageable with the second chamber threads of the modular chamber element, the hub including an administration member coupled thereto, the administration member including a proximal or trailing chamber end and a distal or leading administration end for application to a patient;
- and
- a cap covering the administration end of the administration member, the cap comprising an interior key configured to engage the hub during rotational movement of the cap to thereby cause corresponding rotational movement of the hub whereby the hub threads of the hub threadably engage the second chamber threads of the modular chamber element to move the hub and the administration member from a first transit position to a second activated position, wherein, in the second activated position, the chamber end of the administration member penetrates the chamber seal of the modular chamber element;
- wherein the chamber end of the administration member is disposed within the interior chamber volume of the modular chamber in spaced relation relative to the outlet port of the collar when in the second activated position of the hub and the administration member to access the treatment agent collected in the interior chamber volume of the modular chamber element.
4 more elements
Dependencies are inferred from the claim text.