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US 12,544,489 B2Granted
Fiber-hydrogel composite surgical meshes for tissue repair
AssigneeThe Johns Hopkins University
InventorsRussell Martin, Sashank Reddy, Justin Sacks, Xiaowei Li, Brian Honewee Cho, Hai-Quan Mao
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Abstract
The presently disclosed composition and methods are provided for a hydrogel or nanofiber-hydrogel composite integrated with a surgical scaffold or mesh. A surgical scaffold device comprised of laminar composite is disclosed for the purpose of reducing foreign body response, managing tissue-materials interface, and improving the integration of the surgical mesh with the surrounding tissue of a subject.
Claims15
A surgical device comprising:
- i) a scaffold complex comprising polymeric fibers having a mean diameter of from 100 nm to 8000 nm covalently linked to a hydrogel material;
- wherein the scaffold complex comprises a plurality of pores present on or within a surface of the scaffold complex, wherein the pores are present at a concentration of at least 50 pores per cm2, and wherein at least 80% of the pores have an average pore diameter of at least 5 microns;
- and
- ii) a surgical mesh material.
1 more element
Dependencies are inferred from the claim text.