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US 12,544,442 B2Granted
Biocompatible nanomagnetic discs and methods of use thereof
AssigneeAccudx Corporation
InventorsRaveendran Pottathil, Sanjay Deshmukh, Kiran Kharat
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Abstract
Provided herein are compositions including biocompatible magnetizeable nanoparticles. The nanoparticles have a diameter (average diameter) from about 10 to about 300 nanometers and are biocompatible and magnetic. The nanoparticles may be a disc formed from iron oxide. The disc may be conjugated to a target-binding moiety capable of binding a target. The target may be cancer cells, pathogens, fat cells, or atherosclerotic plaques.
Claims14
A method of treating a subject with a disease condition, the method comprising:
- (i) administering to the subject an effective amount of a composition comprising a magnetizeable nanoparticle, wherein the nanoparticle is disc shaped, has a length from end to end of about 20 to about 150 nanometers, comprises iron oxide and a biocompatible agent, and is conjugated to a target-binding moiety capable of binding a target cell;
- and
- (ii) exposing the subject to an energy source, wherein the energy source is a magnetic field and comprising a variable force variable frequency (VFVF) field of about 1 to about 500 Hz for a time period sufficient to allow the nanoparticle to oscillate, wherein oscillation of the nanoparticle causes disruption, apoptosis, and/or ablation of the target cell.
Dependencies are inferred from the claim text.