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US 12,544,441 B2Granted
Compositions comprising CelTOS immunogens and antibodies and method of use thereof
AssigneesWashington University, University of South Florida
InventorsNaraj H. Tolia, John Jimah, Hirdesh Kumar, John Adams, Francis Ntumngia, Samantha Barnes
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Abstract
The present disclosure provides immunogenic compositions and methods for vaccination with a CelTOS immunogen. The immunogenic composition comprises Babesia, Theileria or Cytauxzoon CelTOS. The immunogenic composition may also comprise CelTOS with structural changes that affect immune recognition.
Claims9
An immunogenic composition comprising a CelTOS variant of Plasmodium vivax, and a suitable adjuvant, wherein the CelTOS variant comprises the sequence set forth in SEQ ID NO:
- 83 with one of the following variations relative to the amino acid sequence set forth in SEQ ID NO:
- 83, (a) a proline to alanine substitution at position 127;
- (b) a deletion of amino acids at positions 165-196;
- (c) a deletion of amino acids at positions 1-50;
- and (d) a lysine to aspartic acid substitution at position 122 and a leucine to aspartic acid substitution at position 164.
2 more elements
Dependencies are inferred from the claim text.