IL-36 secreting immunoresponsive cells and uses thereof
AssigneeMemorial Sloan Kettering Cancer Center
InventorsAnthony Daniyan, Renier J. Brentjens
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Abstract
The present disclosure provides methods and compositions for enhancing the immune response toward cancers and pathogens. It relates to an immunoresponsive cell comprising an antigen-recognizing receptor (e.g., a chimeric antigen receptor (CAR) or a T cell receptor (TCR)), and expressing increased level of IL-36. In certain embodiments, the engineered immunoresponsive cells are antigen-directed and have enhanced immune-activating properties.
Claims19
A method for producing an antigen-specific immunoresponsive cell comprising an exogenous antigen-recognizing receptor that binds to an antigen and an exogenous IL-36 polypeptide or a fragment thereof, the method comprising introducing into an immunoresponsive cell (a) a first nucleic acid sequence encoding the antigen-recognizing receptor;
- and (b) a second nucleic acid sequence encoding the exogenous IL-36 polypeptide, wherein each of the first and second nucleic acid sequence is optionally operably linked to a promoter element.
Dependencies are inferred from the claim text.