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US 12,544,439 B2Granted
Method of treating autoimmune and inflammatory diseases using B cells
AssigneeVersiti Blood Research Institute Foundation, Inc.
InventorBonnie N. Dittel
Life of this patent
Estimating the term…
Abstract
GITRL+ IgDlow/− B cells as well as methods of making and using said cells are described herein. Also described are methods for treating an autoimmune disease or an inflammatory condition in a subject in need thereof of using said B cells. The B cells may be GITRL+ IgDlowCCR7+ CXCR5+ B cells or GITRL+ IgDlow CCR7+ CXCR5+ CD23+ CD24+ B cells.
Claims11
A method for treating an autoimmune disease or an inflammatory condition in a subject in need thereof comprising:
- Administering to the subject in need thereof a therapeutically effective amount of glucocorticoid-induced tumor necrosis factor receptor ligand positive (GITRL+), immunoglobulin D low (IgDlow), CCR7+, CXCR5+ B cells.
Dependencies are inferred from the claim text.