Chimeric RSV and HMPV F proteins, immunogenic compositions, and methods of use
AssigneesEmory University, Children's Healthcare of Atlanta, Inc.
InventorsMartin L. Moore, Sean Todd, Christopher C. Stobart
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Abstract
This disclosure describes a chimeric respiratory syncytial virus encoding a chimeric RSV and hMPV F protein and uses of the chimeric virus or components therein in a vaccine. In certain embodiments, this disclosure describes a live attenuated vaccine comprising an RSV backbone substituting the F proteins of RSV, for a chimeric RSV and hMPV F protein.
Claims20
A chimeric respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) F protein comprising an hMPV F protein ectodomain, an RSV F protein cytoplasmic tail comprising SEQ ID NO:
- 15 or SEQ ID NO:
- 17, and an RSV F protein transmembrane domain, and
- wherein the chimeric respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) F protein comprises SEQ ID NO:
- 1 or a variant having greater than 93% sequence identity to SEQ ID NO:
- 1.
An immunogenic composition comprising a live chimeric virus comprising a nucleic acid encoding
- a chimeric respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) F protein comprising an hMPV F protein ectodomain, an RSV F protein cytoplasmic tail comprising SEQ ID NO:
- 15 or SEQ ID NO:
- 17, and an RSV F protein transmembrane domain, and
- wherein the chimeric respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) F protein comprises SEQ ID NO:
- 1 or a variant having greater than 93% sequence identity to SEQ ID NO:
- 1.
A nucleic acid encoding
- a chimeric respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) F protein comprising an hMPV F protein ectodomain, an RSV F protein cytoplasmic tail comprising SEQ ID NO:
- 15 or SEQ ID NO:
- 17 and an RSV F protein transmembrane domain, and
- wherein the chimeric respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) F protein comprises SEQ ID NO:
- 1 or a variant having greater than 93% sequence identity to SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.