Melanoma canine vaccine compositions and methods of use thereof
AssigneeThe Wistar Institute
InventorsHildegund C. J. Ertl, Xiang Yang Zhou
Life of this patent
Estimating the term…
Abstract
The present invention relates to compositions and methods for generating a nucleic acid delivery system comprising a nucleic acid sequence encoding a heterologous protein comprising a canine tumor-specific antigen (canine melanoma polyepitope (K9Melapoly)) and an inhibitor of an immuno-inhibitory pathway (HSV-1 gD). Additionally, the current invention includes compositions and methods of treating and/or preventing or immunizing a canine against melanoma, and methods of inducing an effector and memory T cell immune response in a canine administered the nucleic acid delivery system of the invention. Furthermore, the invention encompasses a pharmaceutical composition for vaccinating a canine as well as a protein expression system.
Claims21
A composition comprising a nucleic acid delivery system comprising a polynucleotide sequence comprising a promoter sequence operably linked to a nucleic acid sequence encoding a heterologous protein comprising a canine melanoma antigen comprising the amino acid sequence of SEQ ID NO:
- 3 and an inhibitor of an immuno-inhibitory pathway.
A protein expression system comprising a nucleic acid delivery system comprising a polynucleotide sequence comprising a promoter operably linked to a nucleic acid sequence encoding a heterologous protein comprising a canine melanoma antigen comprising the amino acid sequence of SEQ ID NO:
- 3 and an inhibitor of an immuno-inhibitory pathway.
Dependencies are inferred from the claim text.