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US 12,544,404 B2Granted
Compositions and methods for treating bone injury
AssigneeBoard of Regents, The University of Texas System
InventorVaida Glatt
Life of this patent
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Abstract
The disclosure relates to compositions and methods of treating, improving, and accelerating the healing of large segmental bone defects in a subject. The method comprises administering to a patient in need of treatment an effective amount of whole blood, sodium citrate, ecarin and BMP-2.
Claims13
A composition consisting of:
- (a) isolated whole blood;
- (b) sodium citrate;
- (c) thrombin and calcium chloride;
- and (d) bone morphogenetic protein 2 (BMP-2).
1 more element
A method of constructing an implant, the method comprising:
- a) dimensioning a depot implant in at least one of a shape and a size that facilitates implantation of the depot implant into a bone defect;
- and b) structuring the depot implant to have a scaffold by introducing (i) isolated whole blood and sodium citrate;
- (ii) thrombin and calcium chloride;
- and (iii) bone morphogenetic protein 2 (BMP-2) to create the scaffold;
- wherein the scaffold has a porosity of 55 to 75%.
2 more elements
Dependencies are inferred from the claim text.