Compositions of nitrates and methods of use thereof
AssigneeHeartbeet Ltd.
InventorsJon Lundberg, Eddie Weitzberg
Life of this patent
Estimating the term…
Abstract
Inorganic anions nitrate and nitrite influence metabolic rate and glucose homeostasis. Infusion of nitrite iv caused an acute drop in resting energy expenditure (oxygen consumption) and nitrate, when given perorally, caused a reduction in oxygen consumption during exercise and a depression of the increase in blood glucose observed after an oral glucose tolerance test. The doses of nitrate and nitrite did not cause any detectable change in methemoglobin levels of blood. Also, nitrate and nitrite did not alter lactate levels in blood. This discovery provides useful treatments to regulate the energy expenditure and glucose homeostasis of a mammal by administration of inorganic nitrite and/or nitrate.
Claims23
A method of promoting health by improving circulation in a human in need thereof, the method comprising administering inorganic nitrate (NO3−) to the human in an amount of about 0.001-100 mmol inorganic nitrate (NO3−) per kg body weight of the human, whereby administration of the inorganic nitrate (NO3−) improves circulation in the human.
A method of increasing circulation in a human, the method comprising administering inorganic nitrate (NO3−) to the human in an amount of about 0.001-100 mmol inorganic nitrate (NO3−) per kg body weight of the human.
Dependencies are inferred from the claim text.