Biodegradable, antioxidant, thermally responsive injectable hydrogel and uses therefor
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsWilliam R. Wagner, Yasumoto Matsumura, Murugesan Velayutham, Yang Zhu
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Abstract
Provided herein are antioxidant, thermally-responsive polymeric compositions and methods of making and using the compositions, e.g., for treatment of ischemia reperfusion injury or radiation exposure.
Claims11
A method of treating ischemia or an ischemia reperfusion injury at a site in a patient, comprising administering to the patient at the site of the ischemia or ischemia reperfusion injury a thermal responsive, biodegradable copolymer composition, comprising from 70 mole % to 90 mole % of n-isopropylacrylamide (NIPAAm) residues, from 4 mole % to 20 mole % of vinyl pyrrolidone residues, from 4 mole % to 10 mole % of methacrylate-polylactide (MAPLA) residues, and from 0.01 mole % to 10 mole % of TEMPO-containing acrylate or methacrylate residues, the copolymer having a transition temperature between 10° C. and 35° C., above which temperature, the polymer composition transitions from an aqueous-miscible state to a hydrogel having a higher viscosity partially-miscible or immiscible state in an aqueous solution.
A method of treating ischemia or an ischemia reperfusion injury at a site in a patient, comprising administering to the patient at the site of the ischemia or ischemia reperfusion injury a thermal responsive, biodegradable copolymer composition, comprising from 70 mole % to 90 mole % of n-isopropylacrylamide (NIPAAm) residues, from 4 mole % to 20 mole % of vinyl pyrrolidone residues, from 4 mole % to 10 mole % of methacrylate-polylactide (MAPLA) residues, and from 0.01 mole % to 10 mole % acrylate residues, the copolymer having a transition temperature between 10° C. and 35° C., above which temperature, the polymer composition transitions from an aqueous-miscible state to a hydrogel having a higher viscosity partially-miscible or immiscible state in an aqueous solution.
Dependencies are inferred from the claim text.