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US 12,544,393 B2Granted
Apoptosis-mimicking structures for inducing tissue regeneration
AssigneeThe Regents of the University of Michigan
InventorsPeter X. Ma, Laurie K. McCauley, Ming Dang
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Abstract
An apoptosis-mimicking structure includes a polymeric core. The polymeric core includes a polymer backbone. The polymer backbone includes or is modified with a functional group to directly or indirectly bond to an eat me signaling molecule. An eat me signaling molecule is bonded directly or indirectly to the functional group. Other structures include a scaffold and the apoptosis-mimicking structure immobilized on or incorporated into the scaffold.
Claims25
An apoptosis-mimicking structure, consisting of:
- a polymeric core consisting of a polymer backbone and a surface functional group attached to the polymer backbone, the polymer backbone being a synthetic polymer selected from the group consisting of poly (l-lactide), poly (lactide-co-glycolide), polyglycolide, and polycaprolactone;
- a first linking group bonded to the surface functional group;
- a binding protein bonded to the first linking group;
- a second linking group bonded to the binding protein;
- and
- an eat me signaling molecule bonded to the second linking group such that the eat me signaling molecule forms a terminal end group of the apoptosis-mimicking structure, wherein the eat me signaling molecule is phosphatidylserine.
3 more elements
An apoptosis-mimicking structure, consisting of:
- a polymeric core consisting of a polymer backbone and a surface functional group attached to the polymer backbone, the polymer backbone being a synthetic polymer selected from the group consisting of poly (l-lactide), poly (lactide-co-glycolide), polyglycolide, and polycaprolactone;
- and
- an eat me signaling molecule modified with a functional group that covalently bonds to the surface functional group, wherein the eat me signaling molecule is phosphatidylserine, and wherein the eat me signaling molecule functional group is selected from the group consisting of a hydroxyl, an amine, a thiol, a carboxylic acid, an alkene, an alkyne, an alkyl halide, an aldehyde, a ketone, an ester, an amide, and a phenyl.
Dependencies are inferred from the claim text.