Combination therapy using ribociclib and an aromatase inhibitor for the treatment of HR+ breast cancer
AssigneeNovartis AG
InventorsYan Chen, Xizhong Huang, Sunkyu Kim
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Abstract
The present disclosure relates to a pharmaceutical combination comprising (1) a first agent which is a CDK inhibitor or a pharmaceutically acceptable salt thereof and (2) a second agent which is an anti-hormonal agent or a pharmaceutically acceptable salt thereof. The present disclosure also relates to a pharmaceutical combination comprising (1) a first agent which is a CDK inhibitor or a pharmaceutically acceptable salt thereof, (2) a second agent which is an anti-hormonal agent or a pharmaceutically acceptable salt thereof, and (3) a third agent which is an agent that regulates the PI3K/Akt/mTOR pathway or a pharmaceutically acceptable salt thereof.
Claims26
A method of treating HR+ breast cancer in a human, comprising administering to the human an effective amount of Compound A1, or a pharmaceutically acceptable salt thereof:
- and an aromatase inhibitor, wherein the aromatase inhibitor is letrozole or anastrozole.
A method of administering Compound A1, or a pharmaceutically acceptable salt thereof:
- and an aromatase inhibitor to a human HR+breast cancer patient, the method comprising administering Compound A1 and the aromatase inhibitor to the patient to provide therapeutically effective levels of Compound A1 and the aromatase inhibitor in the patient, wherein the aromatase inhibitor is letrozole or anastrozole.
Dependencies are inferred from the claim text.