Compositions and methods for the treatment of Plasmodium falciparum malaria
AssigneesBrown University, Florida Atlantic University Board of Trustees
InventorsJonathan Kurtis, Andrew V. Oleinikov, Dipak K. Raj
Life of this patent
Estimating the term…
Abstract
Described herein are compositions and methods for treating P. falciparum malaria by specifically activating apoptosis in cells that express PfGARP without activating apoptosis in subject host cells or parasite cells that do not express PfGARP.
Claims3
A method of treating P. falciparum malaria comprising administering to a subject in need thereof a therapeutically-effective amount of a small molecule therapeutic agent that specifically binds to P. falciparumglutamic-acid-rich proteins (PfGARP) located on the exofacial surface of red blood cells (RBCs) infected with P. falciparum, wherein the small molecule therapeutic agent is:
Dependencies are inferred from the claim text.