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US 12,544,344 B2Granted
Topical delivery of nucleic acid compounds
AssigneePhio Pharmaceuticals Corp.
InventorsMelissa Maxwell, Richard J. Looby
Life of this patent
Estimating the term…
Abstract
In some aspects, the disclosure relates to RNAi constructs with improved tissue and cellular uptake characteristics and methods of use of these compounds in dermal applications.
Claims9
A pharmaceutical composition formulated in a gel comprising:
- (a) one or more therapeutic oligonucleotides,
- (b) urea present in an amount between about 5% and about 15% w/w,
- (c) lactic acid present in an amount between about 2% and about 10% w/w, and
- (d) a thickening agent, wherein the thickening agent is methylcellulose (MC), and
- wherein the thickening agent is present at about 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, or about 2% w/w, and
- wherein the pharmaceutical composition has a pH of about 3.5.
3 more elements
Dependencies are inferred from the claim text.