Method of manufacturing oral dosage forms for extended drug release
AssigneeCraft Health Pte Ltd.
InventorsSeng Han Lim, Wei Jiang Goh
Life of this patent
Estimating the term…
Abstract
A method for designing and manufacturing a long release capsule for extended delivery of a drug to a patient in an ingestible capsule. The method includes determining a drug volume to be delivered and a drug delivery rate. A buoyancy element is selected based on the drug volume. A release port is selected based on the drug delivery rate and the properties of the drug. The design elements are used to produce a capsule design for an ingestible capsule. The design of the capsule is used to generate manufacturing instructions and produce the capsule.
Claims11
A method for producing a capsule comprising:
- determining a packing volume for packing a releasable agent into a capsule for patient treatment;
- determining a buoyancy volume for the capsule to provide buoyancy to the capsule;
- determining a capsule size based on the packing volume and the buoyancy volume;
- determining a configuration of one or more openings based on at least one physical property of the releasable agent or a releasable agent release rate, wherein the configuration comprises at least one of a number of the one or more openings or a size of at least one opening;
- generating a capsule design having an air compartment, releasable agent compartment, and at least one release outlet based on the packing volume, buoyancy volume, the one or more openings, and the size of the one or more openings;
- and
- generating manufacturing instructions for a manufacturing system to produce the capsule based on the capsule design.
A method of manufacturing a capsule, comprising:
- receiving manufacturing instructions based on a capsule design, the capsule design comprising:
- a first portion comprising a buoyancy chamber and a first interlocking feature;
- a second portion comprising;
- a chamber, the chamber defining an opening providing a conduit between an exterior and an interior of the chamber;
- and
- a second interlocking feature, the second interlocking feature configured to interface with the first interlocking feature to secure the first portion to the second portion and to fully enclose the chamber;
- and
- manufacturing, with a manufacturing system and based on the manufacturing instructions, a long release capsule formed of a gastric acid soluble material.
Dependencies are inferred from the claim text.