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US 12,544,073 B2Granted
Bridging peripheral nerve gaps with conduits for enhanced nerve regeneration
AssigneeNewrotex Limited
InventorsAlexander Woods, Robyn Plowright, Friedrich Vollrath
Life of this patent
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Abstract
Disclosed herein are compositions comprising containers and silk elements. Disclosed herein are methods of regenerating an at least partially severed nerve cell. Disclosed herein are compositions for regenerating an at least partially severed nerve cell.
Claims20
A method comprising:
- a) providing a first plurality of silk elements and a second plurality of silk elements, wherein at least one individual silk element in each plurality of silk elements is at least partially individually coated with a first hydrophilic coating;
- b) at least partially coating with a second hydrophilic coating:
- (i) said first plurality of silk elements to create a first bundle;
- and
- (ii) said second plurality of silk elements to create a second bundle;
- c) bundling at least said first bundle and said second bundle into a bundle of bundles, and at least partially coating said bundle of bundles with a third hydrophilic coating;
- d) bundling at least two of said bundle of bundles into a bundle of bundles of bundles, wherein said bundle of bundles of bundles is at least partially coated with a fourth hydrophilic coating;
- and
- e) placing said bundle of bundles of bundles at least partially within a lumen of a sheath.
6 more elements
A method comprising placing a bundle of bundles of bundles of silk elements into a lumen of a sheath, wherein said bundle of bundles of bundles comprises at least two bundles of bundles, wherein each of said at least two bundles of bundles comprises at least two bundles of silk elements;
- wherein:
- a) each of said at least two bundles of silk elements comprise a plurality of silk elements, wherein each individual silk element in each of said plurality of silk elements comprises a first hydrophilic coating at least partially around said individual silk element;
- b) each of said at least two bundles of silk elements comprises a second hydrophilic coating around each of said at least two bundles of silk elements which holds in place each of said at least two bundles of silk elements;
- c) each of said at least two bundles of bundles comprises a third hydrophilic coating around each of said at least two bundles of bundles which holds in place each of said at least two bundles of bundles;
- and
- d) said bundle of bundles of bundles comprises a fourth hydrophilic coating around said bundle of bundles of bundles which holds in place said bundle of bundles of bundles.
3 more elements
Dependencies are inferred from the claim text.