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US 12,543,980 B2Granted
Determining a platelet aggregation value
AssigneeInstrumentation Laboratory Company
InventorsCory Lee McCluskey, Robert S. Hillman
Life of this patent
Estimating the term…
Abstract
An example system includes a chamber to hold a mixture that includes a whole blood sample from a patient, a light source to illuminate the mixture in the chamber, a detector to detect light from the light source transmitted through the mixture in the chamber, and one or more processing devices to determine, based on the light detected by the detector, a platelet aggregation value of the whole blood sample that is substantially independent of a hematocrit of the whole blood sample.
Claims17
A system comprising:
- a chamber to hold a mixture comprised of a whole blood sample from a patient;
- coated particles or pellets within the chamber, the coated particles or pellets to bind to platelet receptors in the whole blood sample to cause platelet aggregation in the mixture;
- a light source to illuminate the mixture in the chamber;
- a detector to detect light from the light source transmitted through the mixture in the chamber;
- and
- one or more processing devices to perform operations to determine, based on the light detected by the detector, a platelet aggregation value of the whole blood sample that is independent of a hematocrit of the whole blood sample, the operations comprising:
- determining an initial platelet aggregation value of the whole blood sample based on the light detected;
- and
- adjusting the initial platelet aggregation value based on a hematocrit-based correction value to produce the platelet aggregation value.
6 more elements
A method performed on a test instrument, comprising:
- determining, for a whole blood sample in a chamber containing coated particles or pellets, a platelet aggregation value that is independent of a hematocrit of the whole blood sample, the coated particles or pellets to bind to platelet receptors in the whole blood sample to cause platelet aggregation of the whole blood sample in the chamber;
- and
- reporting the platelet aggregation value;
- wherein determining the platelet aggregation value comprises:
- determining an initial platelet aggregation value of the whole blood sample based on light detected through the chamber;
- and
- adjusting the initial platelet aggregation value based on a hematocrit-based correction value to produce the platelet aggregation value.
4 more elements
A system comprising:
- a cartridge comprising multiple chambers, a chamber among the multiple chambers for holding a mixture comprising a whole blood sample to be tested for platelet aggregation, where there is a non-linear relationship between the platelet aggregation and hematocrit for the whole blood sample, and where the chamber contains coated particles or pellets to bind to platelet receptors in the whole blood sample to cause platelet aggregation;
- and
- means for determining, based on the mixture in the chamber, a platelet aggregation value for the whole blood sample, the platelet aggregation value being independent of the hematocrit of the whole blood sample;
- wherein the means for determining is configured to determine the platelet aggregation value by performing operations comprising:
- determining an initial platelet aggregation value of the whole blood sample based on a light detected through the chamber;
- and
- adjusting the initial platelet aggregation value based on a hematocrit-based correction value to produce the platelet aggregation value.
4 more elements
Dependencies are inferred from the claim text.