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US 12,540,940 B2Granted
Biomarkers for the early detection of breast cancer
AssigneesPresident and Fellows of Harvard College, Arizona Board of Regents, Dana-Farber Cancer Institute, Inc.
InventorsJoshua Labaer, Karen Sue Anderson, Garrick Wallstrom, Sahar Sibani, Niroshan Ramachandran
Life of this patent
Estimating the term…
Abstract
The present invention provides reagents and methods for breast cancer detection.
Claims4
A polynucleotide array comprising:
- (a) a support;
- and
- (b) at least 2 different isolated nucleic acids encoding polypeptides selected
- from the group consisting of ATP6AP1 (SEQ ID NO:
- 14), PDCD6IP (SEQ ID NO:
- 22), DBT (SEQ ID NO:
- 26), CSNKIE (SEQ ID NO:
- 10), FRS3 (SEQ ID NO:
- 4), HOXD1 (SEQ ID NO:
- 8), SF3A1 (SEQ ID NO:
- 2), C15orf48 (SEQ ID NO:
- 36), MYOZ2 (SEQ ID NO:
- 34), BAT4 (SEQ ID NO:
- 6), BMX (SEQ ID NO:
- 46), RAB5A (SEQ ID NO:
- 24), UBAP1 (SEQ ID NO:
- 48), GPR157 (SEQ ID NO:
- 44), ZMYM6 (SEQ ID NO:
- 42), SLC33A1 (SEQ ID NO:
- 12), TRIM32 (SEQ ID NO:
- 38), ALG10 (SEQ ID NO:
- 28), TFCP2 (SEQ ID NO:
- 50), SERPINH1 (SEQ ID NO:
- 52), SELL (SEQ ID NO:
- 56), ZNF510 (SEQ ID NO:
- 54), or antigenic fragments thereof, attached to the support wherein the array comprise no more than 100 different isolated nucleic acids;
- wherein the polynucleotide array is a Nucleic Acid Protein Programmable Array.
24 more elements
Dependencies are inferred from the claim text.