Desalting system for chromatography

An analytical system comprising:

• a) a pump configured to pump a mobile phase;
• b) an injection valve configured to input a sample into the mobile phase, the injection valve is fluidly coupled to an output of the pump;
• c) a chromatography column configured to separate the sample into one or more analytes, the chromatography column fluidly coupled to an output of the injection valve;
• d) an ion removal device configured to remove at least ions of one charge from the mobile phase, the ion removal device fluidly coupled to an output of the chromatography column;
• e) an ion selective sensor configured to measure a signal corresponding to an activity of the at least ions of one charge in the mobile phase, the ion selective sensor fluidly coupled to an output of the ion removal device;
• f) an optional diverter valve that can interrupt a flow of the mobile phase;
• and
• g) a microprocessor configured to monitor the signal of the ion selective sensor and when the signal is greater than a predetermined threshold to either switch the optional diverter valve to interrupt the flow of the mobile phase or turn off the pump.