Micro-balance biosensors to detect whole viruses
AssigneeUniversity of Utah Research Foundation
InventorMassood Tabib-Azar
Life of this patent
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Abstract
The present disclosure describes methods of detecting viral biomolecules such as viruses through frequency response. A method (200) of detecting a vims includes exposing (210) a sensor surface to a fluid sample containing a suspected virus. The sensor surface can be a surface of a resonator having a clean resonant frequency from about 1 MHz to about 1 GHz. The surface can be modified with molecular recognition groups selective for binding to the viral biomolecule. A resonant frequency of the resonator can be measured (220) after exposing the sensor surface to the fluid sample. The measured resonant frequency can be compared (230) with a clean resonant frequency indicating the presence of the viral biomolecule bound to the molecular recognition groups and then outputted (240) as a detection signal.
Claims19
A method of detecting a virus, comprising:
- exposing a sensor surface to a fluid sample containing a suspected virus, wherein the sensor surface is a surface of a resonator having a clean resonant frequency from about 1 MHz to about 1 GHz, wherein the surface is modified with molecular recognition groups selective for binding to a viral biomolecule;
- measuring a resonant frequency of the resonator after exposing the sensor surface to the fluid sample;
- comparing the measured resonant frequency with the clean resonant frequency indicating the presence of the viral biomolecule bound to the molecular recognition groups;
- comparing the measured resonant frequency with a correlation of resonant frequency to mass of viral biomolecule bound to the molecular recognition groups;
- and
- outputting a detection signal, wherein outputting a detection signal comprises outputting a calculated mass of viral biomolecule bound to the molecular recognition groups.
A microbalance whole virus sensor, comprising:
- a resonator having a sensor surface with a clean resonant frequency from 1 MHz to 1 GHz and the sensor surface including molecular recognition groups attached to the sensor surface, wherein the molecular recognition groups selectively bind with a viral biomolecule;
- and
- a processor which compares the clean resonant frequency to a measured resonant frequency when the viral biomolecule binds with the molecular recognition groups to identify presence of the viral biomolecule,
- wherein the processor further compares the measured resonant frequency with a correlation of resonant frequency to mass of viral biomolecule bound to the molecular recognition groups to output a calculated mass of viral biomolecule bound to the molecular recognition groups.
Dependencies are inferred from the claim text.