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US 12,540,192 B2Granted
CD20 binding single domain antibodies
AssigneesVib Vzw, Universiteit Gent
InventorsJan Tavernier, Anje Cauwels, José Van Der Heyden
Life of this patent
Estimating the term…
Abstract
The present application relates, in part, to agents that bind CD20 and their use as therapeutic agents. The present application further relates to pharmaceutical compositions comprising the CD20 binding agents and their use in the treatment of various diseases.
Claims16
A CD20 binding agent comprising at least one targeting moiety comprising a single-domain antibody comprising three complementarity determining regions (CDR1, CDR2, and CDR3), wherein:
- (a) CDR1 comprises the amino acid sequence of SEQ ID NO:
- 35, CDR2 comprises the amino acid sequence of SEQ ID NO:
- 46, and CDR3 comprises the amino acid sequence of SEQ ID NO:
- 56;
- (b) CDR1 comprises the amino acid sequence of SEQ ID NO:
- 35, CDR2 comprises the amino acid sequence of SEQ ID NO:
- 47, and CDR3 comprises the amino acid sequence of SEQ ID NO:
- 56;
- (c) CDR1 comprises the amino acid sequence of SEQ ID NO:
- 36, CDR2 comprises the amino acid sequence of SEQ ID NO:
- 46, and CDR3 comprises the amino acid sequence of SEQ ID NO:
- 56;
- (d) CDR1 comprises the amino acid sequence of SEQ ID NO:
- 37, CDR2 comprises the amino acid sequence of SEQ ID NO:
- 46, and CDR3 comprises the amino acid sequence of SEQ ID NO:
- 56;
- (e) CDR1 comprises the amino acid sequence of SEQ ID NO:
- 38, CDR2 comprises the amino acid sequence of SEQ ID NO:
- 48, and CDR3 comprises the amino acid sequence of SEQ ID NO:
- 57;
- (f) CDR1 comprises the amino acid sequence of SEQ ID NO:
- 39, CDR2 comprises the amino acid sequence of SEQ ID NO:
- 49, and CDR3 comprises the amino acid sequence of SEQ ID NO:
- 58;
- (g) CDR1 comprises the amino acid sequence of SEQ ID NO:
- 40, CDR2 comprises the amino acid sequence of SEQ ID NO:
- 50, and CDR3 comprises the amino acid sequence of SEQ ID NO:
- 59;
- or
- (h) CDR1 comprises the amino acid sequence of SEQ ID NO:
- 41, CDR2 comprises the amino acid sequence of SEQ ID NO:
- 50, and CDR3 comprises the amino acid sequence of SEQ ID NO:
- 60.
30 more elements
Dependencies are inferred from the claim text.