Anti-BCMA antibody, antigen-binding fragment thereof and medical use thereof
AssigneesShanghai Hansoh Biomedical Co., Ltd., Jiangsu Hansoh Pharmaceutical Group Co., Ltd.
InventorsHaiqing Hua, Rudi Bao
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Abstract
Provided are an anti-BCMA antibody, an antigen-binding fragment thereof, and a medical use thereof. Further provided are a chimeric antibody and a humanized antibody containing a CDR region of the anti-BCMA antibody, a pharmaceutical composition containing the anti-BCMA antibody or the antigen-binding fragment thereof, and the use of same as an anti-cancer drug and for treating autoimmune diseases. Particularly, provided are a humanized anti-BCMA antibody, and the use of same in the preparation of a drug for treating BCMA-mediated diseases or conditions and the use of same in disease detection and diagnosis.
Claims20
An anti-BCMA antibody or antigen-binding fragment thereof, which comprises a heavy chain variable region and a light chain variable region, wherein the heavy chain variable region comprises HCDR1 as shown in SEQ ID NO:3, HCDR2 as shown in SEQ ID NO:4 and HCDR3 as shown in SEQ ID NO:5;
- and the light chain variable region comprises LCDR1 as shown in SEQ ID NO:6, LCDR2 as shown in SEQ ID NO:7 and LCDR3 as shown in SEQ ID NO:
- 8.
Dependencies are inferred from the claim text.