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US 12,540,182 B2Granted
Chimeric antigen receptor, macrophage expressing same, method for adjusting macrophage polarization, and use thereof
AssigneeZhejiang University
InventorsJin Zhang, Lin Tian, Anhua Lei
Life of this patent
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Abstract
Provided are a chimeric antigen receptor, a macrophage expressing same, a method for adjusting macrophage polarization, and the use thereof. The intracellular domain of the chimeric antigen receptor contains an IFN-γ receptor, and the macrophage expressing the chimeric antigen receptor can maintain an M1 type status for a relatively long time, thereby enhancing the activity of the macrophage M1 type after tumor cell antigens are combined with the chimeric antigen receptor.
Claims3
A chimeric antigen receptor, wherein an extracellular domain of the chimeric antigen receptor contains scFv targeting mesothelin;
- a transmembrane region contains CD8α;
- and an intracellular domain contains a costimulatory molecule 4-1BB, CD3ζ, and IFN-γ receptor;
- and
- an amino acid sequence of the chimeric antigen receptor is shown by SEQ ID NO.1, or shown by a sequence that is at least 90% or more identical homologous with the sequence shown by SEQ ID NO.1.
1 more element
Dependencies are inferred from the claim text.