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OwnerPavel Mikhailovich Gershovich, Aleksandr Vladimirovich Karabelskii +4inventors
InventorsPavel Mikhailovich Gershovich, Aleksandr Vladimirovich Karabelskii, Andrei Borisovich Ulitin, Dmitrij Aleksandrovich Madera, Roman Alexeevich Ivanov, Dmitry Valentinovich Morozov
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The present invention relates to the field of biotechnology, specifically to an isolated alternative intracellular signalling domain of a chimeric antigen receptor (CAR) and to a chimeric antigen receptor (CAR) comprising, said signalling domain. The invention also relates to a nucleic acid coding an alternative intracellular signalling domain of a chimeric antigen receptor, and to a nucleic acid coding a chimeric antigen receptor with the above-mentioned signalling domain, to an expression vector, to a delivery vector, and also a genetically modified cell which comprises the above-mentioned chimeric antigen receptor, and to a method for producing said cell.
An isolated alternative intracellular signaling domain of a chimeric antigen receptor (CAR), wherein immunoreceptor tyrosine-based activation motif ITAM3 is substituted with the amino acid sequence of integrin beta 3 (ITGB3).
Dependencies are inferred from the claim text.