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US 12,540,166 B2Granted
BNIP3 peptides for treatment of reperfusion injury
AssigneeBimyo GmbH
InventorsTienush Rassaf, Ulrike Hendgen-Cotta
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Abstract
The invention provides peptides capable of inhibiting the individual activity and inter-pathway communication of BNIP3, BAX and mitochondria. The peptides can be used in methods of treating a disease or condition in a subject in which it is desirable to prevent cell damage and cell death.
Claims18
A peptide comprising (i) a cellular uptake signal;
- and (ii) a BCL-2 adenovirus E1B 19 kDa interacting protein-3 (BNIP3) fragment that differs by no more than 2 residues from the BNIP3 fragment of SEQ ID NO:8, and wherein the residue at position 7 of the BNIP3 fragment is phenylalanine, and wherein the peptide has a length of no more than 50 amino acids.
A peptide of no more than 50 amino acids, the peptide comprising a cellular uptake signal comprising the amino acid sequence selected from the group consisting of SEQ ID NO:
- 31 to SEQ ID NO:
- 50, and a BNIP3 fragment comprising the amino acid sequence of SEQ ID NO:8.
Dependencies are inferred from the claim text.