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US 12,540,164 B2Granted
Peptides for treatment and prevention of nonalcoholic fatty liver disease and fibrosis
AssigneesUniversite De Strasbourg, Inserm (Institut National De La Sante Et De La Recherche Medicale)
InventorVincent Marion
Life of this patent
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Abstract
The present invention relates to peptides for the treatment or prevention of nonalcoholic fatty liver disease (NAFLD), non-alcoholic fatty liver (NAFL), non-alcoholic steatohepatitis (NASH), hepatic steatosis (fatty liver), liver inflammation, cirrhosis, hepatocellular carcinoma or fibrosis, especially liver fibrosis.
Claims6
A peptide comprising:
- (SEQ ID NO:
- 25)
- VECTXXEKRVLAX;
- (SEQ ID NO:
- 26)
- VECTMXEKXVLAX;
- (SEQ ID NO:
- 27)
- VECTXXEKXVLAX;
- (SEQ ID NO:
- 28)
- VECTXXEKXVLAXLDKXXFLTQLHS;
- (SEQ ID NO:
- 29)
- VECTMXEKRVLAXLDKXXFLTQLHS;
- (SEQ ID NO:
- 30)
- VECTXXEKRVLAXLDKPPFLTQLHS;
- (SEQ ID NO:
- 31)
- VECTMXEKXVLAXLDKPPFLTQLHS;
- wherein the residues which are bold and underlined X are stapled and is any amino acid derivative suitable for stapling;
- and
- wherein X is any amino acid except M, P and R.
21 more elements
Dependencies are inferred from the claim text.