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US 12,540,148 B2Granted
Lipophosphonoxins, their preparation and use
AssigneesUstav Organicke Chemie A Biochemie Av Cr, V.V.I., Mikrobiologicky Ustav Av Cr, V.V.I., Univerzita Palackeho V Olomouci
InventorsDominik Rejman, Radek Pohl, Viktor Mojr, Duy Dinh Do Pham, Milan Kolar, Libor Krasny
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Abstract
Lipophosphonoxins of general formula I, diastereomers and mixtures of diastereomers of compounds of general formula I and their pharmaceutically acceptable salts and hydrates as antibacterial agents, forming an active ingredient in pharmaceutical compositions for the treatment of resistant bacterial infections, disinfectants and/or selective culture media is disclosed.
Claims7
A lipophosphonoxin of the general formula I
- wherein:
- the X substituent is independently selected from the following structures:
- wherein m=1-3;
- the Y1 and Y2 substituents are independently selected from the following structures:
- wherein n=0-12, and o=0-12, and p=0-12, and
- R1, R2, R3, R4, and R5 are independently selected from the group consisting of:
- H—, CH3—, CH2CH3, propyl, isopropyl, isobutyl, tert-butyl, CH3O—, CH2CH3O—, propoxy, isopropoxy, isobutyloxy or tert-butyloxy;
- and
- the Z substituent is selected from the following structures:
- wherein q=2-14, and r=0-10, and s=0-10,
- or a diastereomer or a mixture of diastereomers of the lipophosphonoxin of formula I, or a pharmaceutically acceptable salt or hydrate thereof.
8 more elements
Dependencies are inferred from the claim text.