Crystal form I of curcumin derivative, preparation method therefor and application thereof
AssigneesWenzhou Medical University, Wenzhou Guangcheng Biotech Co., Ltd.
InventorsGuang Liang, Wenqi Wu, Jianchang Qian, Di Wu, Yi Wang
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Abstract
Provided are a crystal form I of a curcumin derivative (C66), a preparation method therefor and an application thereof. An X-ray powder diffraction pattern of the crystal form I contains following characteristic peaks for 2θ reflection angle determination: 8.4±0.2°, 11.5±0.2°, 13.1±0.1°, 16.6±0.2°, 18.8±0.1°, and 21.2±0.1°. No sharp diffraction peak exists at 33.5±0.2° and 38.1±0.2°. A structure of the curcumin derivative is shown in formula (I) as follows:
Claims9
A crystal form I of a curcumin derivative, an X-ray powder diffraction pattern of which contains following characteristic peaks for 2θ reflection angle determination:
- 8.4±0.2°, 11.5±0.2°, 13.1±0.1°, 16.6±0.2°, 18.8±0.1°, and 21.2±0.1°;
- wherein no sharp diffraction peak exists at 33.5±0.2° and 38.1±0.2°;
- a structure of the curcumin derivative is shown in formula (I) as follows:
A preparation method for a crystal form I of a curcumin derivative, wherein an X-ray powder diffraction pattern of the crystal form I contains following characteristic peaks for 2θ reflection angle determination:
- 8.4±0.2°, 11.5±0.2°, 13.1±0.1°, 16.6±0.2°, 18.8±0.1°, and 21.2±0.1°;
- wherein no sharp diffraction peak exists at 33.5±0.2° and 38.1±0.2°;
- a structure of the curcumin derivative is shown in formula (I) as follows:
- the preparation method comprises:
- dissolving the curcumin derivative in an organic solvent, filtering with a 0.22 μm filter to obtain a filtrate, slowly evaporating the filtrate at room temperature and humidity, precipitating crystals, filtering, and drying to obtain the crystal form I;
- wherein the organic solvent comprises one or more of methanol, ethanol, acetone, isopropanol, ethyl acetate, toluene, acetonitrile, methyl tert-butyl ether, isopropyl acetate, heptane, and methyl isobutyl ketone.
A preparation method for a crystal form I of a curcumin derivative, wherein an X-ray powder diffraction pattern of the crystal form I contains following characteristic peaks for 2θ reflection angle determination:
- 8.4±0.2°, 11.5±0.2°, 13.1±0.1°, 16.6±0.2°, 18.8±0.1°, and 21.2±0.1°;
- wherein no sharp diffraction peak exists at 33.5±0.2° and 38.1±0.2°;
- a structure of the curcumin derivative is shown in formula (I) as follows:
- the preparation method:
- dissolving the curcumin derivative in a first organic solvent, filtering with a 0.22 μm filter to obtain a filtrate, mixing the filtrate with an equal volume of a second organic solvent to obtain a mixture, slowly evaporating the mixture at room temperature and humidity, precipitating crystals, filtering, and drying to obtain the crystal form I;
- wherein the first organic solvent comprises one or more of methanol, ethanol, acetone, isopropanol, toluene, 1,4-dioxaohexane, methyl tert-butyl ether, isopropyl acetate, heptane, or methyl isobutyl ketone;
- the second organic solvent comprises one or more of methanol, ethanol, acetone, isopropanol, ethyl acetate, toluene, 1,4-dioxaohexane, acetonitrile, methyl tert-butyl ether, isopropyl acetate, or methyl isobutyl ketone.
Dependencies are inferred from the claim text.