Dialysis apparatus which ultra-filters blood and a related method

A hemodialysis apparatus for ultrafiltering blood from a patient, the hemodialysis apparatus comprising:

• a first dialyzer circuit which includes a first hemodialyzer including a blood compartment and a dialysate compartment separated by a first hemodialyzer membrane which filters blood in that is forced into the blood compartment thereof by at least a first pump, the dialysate compartment being fed with dialysate pumped thereinto by at least a second pump through a first side of a first balance chamber and outputting hemodiafiltrate into a blood compartment of a second hemodialyzer, an output of the blood compartment of the first hemodialyzer being combined with an output of the blood compartment of the second hemodialyzer to generate blood out;
• a second dialyzer circuit which facilitates dissociation of plasma protein bound uremic toxins, the second dialyzer circuit including the second hemodialyzer with a second hemodialyzer membrane which separates the uremic toxins from the plasma protein by ultrafiltration to output a residue of the hemodiafiltrate containing concentrated plasma protein from the blood compartment of the second hemodialyzer for recirculation to the blood out to the patient, at least a third pump being connected between an output from the first hemodialyzer and an input to the blood compartment of the second hemodialyzer, and a dialysate compartment output comprising a filtrate of the hemodiafiltrate from the second hemodialyzer being pumped through a second side of the first balance chamber;
• and a second balance chamber connected to the second hemodialyzer,
• the first hemodialyzer membrane is more porous than the second hemodialyzer membrane.