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US 12,539,349 B2Granted
Biocompatible tissue-adhesive polymers
AssigneesTechnion Research & Development Foundation Limited, Children's Medical Center Corporation
InventorsBoaz Mizrahi, Alona Shagan, Dan Kohane, Wei Zhang
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Abstract
The present invention provides a branched biodegradable and biocompatible polymer (e.g. polycaprolactone) and use thereof in bioadhesion of at least one biological surface.
Claims15
A branched polymer comprising a plurality of biodegradable arms, wherein:
- said plurality of arms is at least 4 arms and each of said plurality of arms comprises a tissue-binding group;
- each of said plurality of biodegradable arms is a polyester;
- a total number of repeating units of said polyester in the branched polymer is between 70 and 180;
- the melting point of said branched polymer is in the range from 42 to 50° C.;
- the branched polymer is a tissue sealant characterized by tissue adhesion strength of more than 0.5N;
- the elastic modulus of said branched polymer is in the range from 10 to 200 kPa.
3 more elements
Dependencies are inferred from the claim text.