Exosomes for target specific delivery and methods for preparing and delivering the same
AssigneesIlias Biologics Inc., Ilias Therapeutics, Inc.
InventorsChulhee Choi, Nambin Yim, Hojun Choi, Kyungsun Choi, Seung-Wook Ryu
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Abstract
The present invention provides a method for producing an exosome that transfers an active substance specifically to a target and the exosome produced by the same; a method for delivering the active substance to the target tissue using the exosome; a pharmaceutical composition for delivery of the active substance comprising the exosome as an active ingredient; and a composition for preparing the exosome comprising an expression vector wherein the target peptide is inserted into an extracellular portion of a transmembrane protein.
Claims20
An exosome comprising
- CD9,
- a target peptide inserted between amino acids corresponding to amino acid positions 167 and 181 from the N-terminus of SEQ ID NO:
- 3, and
- one or more active substance(s).
A pharmaceutical composition comprising;
- an exosome comprising a target peptide inserted between amino acids corresponding to amino acid positions 167 and 181 from the N-terminus of SEQ ID NO:
- 3;
- and,
- one or more active substance(s).
Dependencies are inferred from the claim text.