Anti-psychotic composition and treatment methods
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsKadiamada N. Chengappa, Dean Francis Salisbury
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Abstract
Provided herein are methods of treatment of psychiatric disorders requiring treatment with an antipsychotic drug, such as schizophrenia or schizoaffective disorder, comprising administration of both the antipsychotic drug and a W. somnifera plant part, extract, chemical constituent(s) thereof, or a derivative thereof to treat symptoms of the psychiatric disorder. Treatment is typically continued for at least four weeks. A combination dosage form comprising both the antipsychotic drug and the W. somnifera plant part, extract, chemical constituent(s) thereof, or a derivative thereof in amounts effective to treat the psychiatric disorder.
Claims20
A method of treating one or more negative symptoms of schizophrenia or schizoaffective disorder in a patient experiencing an exacerbation of negative symptoms, comprising:
- administering, to a patient experiencing an exacerbation of negative symptoms, a Withania somnifera active agent in combination with an antipsychotic active agent, wherein the W. somnifera active agent is administered for at least four weeks in an amount of from 100 mg to 2000 mg twice daily, and wherein the combination of the W. somnifera active agent and the antipsychotic active agent treats the one or more negative symptoms of schizophrenia or schizoaffective disorder in the patient experiencing an exacerbation of negative symptoms within four weeks of initiation of administration.
A method of treating one or more negative symptoms of schizophrenia or schizoaffective disorder in a patient experiencing an exacerbation of negative symptoms, comprising:
- administering to the patient experiencing an exacerbation of negative symptoms:
- a first active agent consisting of a Withania somnifera active agent;
- and
- a second active agent comprising an antipsychotic active agent,
- wherein the W. somnifera active agent is administered for at least four weeks in an amount of from 100 mg to 2000 mg twice daily, and
- wherein the combination of the W. somnifera active agent and the antipsychotic active agent treats the one or more negative symptoms of schizophrenia or schizoaffective disorder in the patient experiencing an exacerbation of negative symptoms within four weeks of initiation of administration.
A method of treating one or more negative symptoms of schizophrenia or schizoaffective disorder in a patient, comprising:
- administering, to a patient a Withania somnifera active agent in combination with an antipsychotic active agent,
- wherein the patient exhibits a score of at least 4 for at least two symptoms of the Positive and Negative Syndrome Scale Negative Symptom Subscale (PANSS-NSS),
- wherein the W. somnifera active agent is administered for one week in an amount of 250 mg twice daily, and is thereafter administered in an amount of 500 mg twice daily for at least eleven weeks,
- wherein the combination of the W. somnifera active agent and the antipsychotic active agent treats the one or more negative symptoms of schizophrenia or schizoaffective disorder in the patient, and wherein treating the one or more negative symptoms comprises an improvement in at least one or more items of the PANSS-NSS within four weeks of initiation of administration.
Dependencies are inferred from the claim text.