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US 12,539,311 B2Granted
Short-acting heparin-based anticoagulant compounds and methods
AssigneeThe University of North Carolina at Chapel Hill
InventorsJian Liu, Zhangjie Wang, Po-Hung Hsieh, Yongmei Xu
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Abstract
Heparin compounds and synthetic heparin analogues having short acting anticoagulant activity are provided. Methods of synthesizing such heparin compounds, including chemoenzymatic pathways using sulfotransferase enzymes are provided. Methods of treating subjects in need of anticoagulant activity are provided.
Claims22
A synthetic heparin analogue
- having a structure selected from the group consisting of:
- wherein R is selected from the group consisting of —H, alkyl, substituted alkyl, aryl, and substituted aryl.
Dependencies are inferred from the claim text.