Oral thin films
AssigneeUniversity of Strathclyde
InventorAlexander Balfour Mullen
Life of this patent
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Abstract
An orally dissolvable film includes at least one layer comprising a first pharmaceutically active ingredient; a resinate comprising an ion exchange resin and a second pharmaceutically active ingredient; and a matrix and/or binder. The provision of a first pharmaceutically active ingredient, e.g., dispersed or dissolved in the film, and of a resinate comprising an ion exchange resin and a second pharmaceutically active ingredient, may allow immediate release of the first active ingredient, and controlled, sustained and/or delayed release of the second active ingredient.
Claims19
An orally dissolvable film including at least one layer, wherein a first layer of the at least one layer comprises a non-complexed first pharmaceutically active ingredient that provides an immediate release rate:
- said first layer of said at least one layer further comprising a resinate comprising an ion exchange resin that provides a controlled and/or delayed release rate for a second pharmaceutically active ingredient, and a matrix and/or binder, wherein the immediate release rate is selected from the group consisting of at least a 30% release of said first pharmaceutically active ingredient and at least a 50% release of said first pharmaceutically active ingredient, during the first 5 minutes, when measured at pH 6.8, and wherein the controlled and/or delayed release rate is selected from the group consisting of about a 5-80% release of the second pharmaceutically active ingredient and about a 10-60% release of the second pharmaceutically active ingredient, after 1 hour, when measured at pH 6.8.
Dependencies are inferred from the claim text.