External nano liniment for gout and preparation method thereof

An external nano liniment for external treatment of gout, comprising:

• a cream phase;
• and
• nanoparticles, dispersed in the cream phase,
• wherein the nanoparticles are of a coating structure having a water phase, an oil phase and a water phase in sequence from inside to outside,
• active ingredients used for treating the gout are embedded or dispersed in the water phase and/or the oil phase of the nanoparticles,
• a size distribution of the nanoparticles is in a range of 1-200 nm,
• the active ingredients comprise at least one of 4-hydroxymethyl phenylbeta-D-glucopyranoside, febuxostat, allopurinol, benzbromarone, colchicine, topiroxostat, lesinurad, etoricoxib, meloxicam, diclofenac sodium, diclofenac potassium, probenecid, indometacin, loxoprofen, piroxicam, dexketoprofen trometamol, acetohexamide, camphor, borneol and mint, and
• when the active ingredients are a single active ingredient, a content of the active ingredients is 0.1-5% with respect to a total weight of the nano liniment when the nano liniment is externally applied to gout parts twice a day for 1-6 weeks, and when the active ingredients are multiple active ingredients, a sum content of the active ingredients is 0.4-5% with respect to the total weight of the nano liniment, when the nano liniment is externally applied to the gout parts twice a day for 1-6 weeks.