Methods and devices for blood displacement-based localized treatment
AssigneeTechnion Research & Development Foundation Limited
InventorsMark Epshtein, Netanel Korin
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Abstract
Disclosed herein is a method for providing localized treatment at a target site in a blood vessel of a subject. The method includes (i) delivering to a vicinity of a target site in a blood vessel a water-immiscible fluid such as to displace blood from the vicinity of the target site, and (ii) administering an active agent to the target site, wherein the water-immiscible fluid and the active agent are mutually immiscible, or substantially mutually immiscible, so that the active agent is trapped by the water-immiscible fluid.
Claims13
A method for providing a localized treatment at an aneurysm in a blood vessel of a subject, the aneurysm comprising an aneurysm cavity and an aneurysm neck positioned between a main lumen of the blood vessel and the aneurysm cavity, the method comprising:
- delivering a water-immiscible fluid to the aneurysm neck so as to temporarily fluidly-isolate the aneurysm neck from a blood circulation, and so as to form a barrier to a blood flow at the aneurysm neck, thereby fluidly-isolating the aneurysm cavity from the main lumen of the blood vessel, wherein the water-immiscible fluid is prevented from penetrating into the aneurysm cavity;
- and
- administering an active agent to the aneurysm cavity, wherein the water-immiscible fluid and the active agent are substantially mutually immiscible, so that the active agent is trapped by the water-immiscible fluid, wherein at least a portion of the active agent is delivered into the aneurysm, the active agent being configured to form or to induce a formation of a blood clot in the aneurysm cavity.
Dependencies are inferred from the claim text.